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Top Song(s)
• Sophie Tucker - Some of These Days
• Original Dixieland Jazz Band - Tiger Rag
• Al Jolson - Rock-A-Bye Your Baby (With a Dixie Melody)
• Marion Harris - After You've Gone
• Chauncy Olcott - When Irish Eyes Are Smiling
Top Film(s)
• Frankenstein
• A Trip to Mars
• The Automatic Moving Company
• The House with Closed Shutter
• The Wonderful Wizard of Oz
Best Selling Book(s)
• Howards End - E.M. Forster
• The Phantom of the Opera - Gaston Leroux
• The Secret Garden - Frances Hodgson Burnett
• The Emerald City of Oz - L. Frank Baum
• The Ransom of Red Chief - O. Henry
Famous Deaths
• January 12 – Bass Reeves, one of the first black Deputy U.S. Marshals west of the Mississippi River.
• January 27 - Thomas Crapper, English plumber, bathroom fittings seller who contributed to sanitary engineering.
• April 21 – Mark Twain, writer, entrepreneur, publisher and lecturer.
• May 6 - Edward VII, King of England (1901-10).
• May 31 - Elizabeth Blackwell, English-American physician, the first woman to receive a medical degree in the United States.
• June 23 – John McGraw, 2nd Governor of Washington.
• July 4 - Giovanni Schiaparelli, Italian astronomer (discovered canals of Mars).
• July 12 - Charles Rolls, British aviator and auto manufacturer who co-founded Rolls Royce.
• September 18 – Lelia P. Roby, philanthropist; founder, Ladies of the Grand Army of the Republic.
• October 17 – Julia Ward Howe, abolitionist and poet.
Medical/Science/Technology
• Great January Comet of 1910 first observed.
• Umetaro Suzuki isolates the first vitamin complex, aberic acid.
• Hoechst AG market Arsphenamine under the trade name Salvarsan.
• George Barger and James Ewens of Wellcome Laboratories in London first synthesize dopamine.
• German physicist Theodor Wulf climbs the Eiffel Tower with an electrometer and discovers the 1st evidence of cosmic rays.
• The first pyloromyotomy, a surgery to correct the congenital narrowing is performed.
• Peyton Rous demonstrates that a malignant tumor can be transmitted by a virus.
• Hans Christian Jacobaeus of Sweden performs the first thoracoscopic diagnosis with a cystoscope.
• A patent for the first safety catch (firearms) is filed by the Browning Arms Company in the United States.
• Georges Claude demonstrates the first modern neon light at the Paris Motor Show.
Political Events
• March 19 – Republicans reduce the powers of the Speaker of the House of Representatives to influence committee membership.
• March 22 – President of the United States William H. Taft gives an endorsement in favor of creating a "World Court".
• March 30 – The Mississippi Legislature founds The University of Southern Mississippi.
• May 11 – The U.S. Congress establishes Glacier National Park in Montana.
• May 16 – The U.S. Congress authorizes the creation of the United States Bureau of Mines.
• June 25 - The Mann Act, known popularly as the "White Slave Traffic Act", is passed by the U.S. Congress.
• June 25 - The U.S. Parole Commission is created.
• June 25 - The United States Postal Savings System is created by law.
• June 25 - The Pickett Act becomes law, giving the president authority to withdraw government-owned land from public use.
• December 19 – Edward Douglass White is sworn in as the 9th Chief Justice of the United States.
National Events
• January 10 – Joyce Hall founds Hallmark Cards.
• February 1 – A coal mine explosion at the Browder Coal Company in Drakesboro, Kentucky kills 34 miners.
• February 16–18 – The state of Ohio is crippled by a snowstorm.
• March 12 – American actress Florence Lawrence becomes "the first true movie star" after being named in advertisements.
• April 10 – Halley's Comet becomes visible with the naked eye.
• June 19 – The first unofficial Father's Day is observed.
• August 20–21 – The Great Fire of 1910 wildfire burns about 3 million acres.
• October 1 – A bomb explodes at the Los Angeles Times building, leaving 21 dead and several injured.
• November 4 – Antonio Rodríguez is burned at the stake near Rocksprings, Texas.
• November 7 – The first air flight for the purpose of delivering commercial freight takes place in the United States.
Worldwide Events
• February 12 – Chinese expedition to Tibet: A force of 2,000 Chinese troops march into Lhasa, the capital of Tibet.
• February 20 – Boutros Ghali, the first native-born Prime Minister of Egypt, is assassinated in Cairo.
• March 10 - Slavery in China, which has existed since the Shang dynasty, is now made illegal.
• April 5 – The Transandine Railway connecting Chile and Argentina is inaugurated.
• May 6 – George V becomes King of the United Kingdom of Great Britain and Ireland upon the death of his father, Edward VII.
• May 31 – The Union of South Africa is created.
• July 24 – Ottoman forces capture the city of Shkoder to put down the Albanian Revolt of 1910.
• August 28 – Montenegro is proclaimed an independent kingdom, under Nicholas I.
• August 29 – Emperor Sunjong of Korea abdicates and the country's monarchy is abolished.
• November 20 – The Mexican Revolution begins, when Francisco I. Madero proclaims the elections of 1910 null and void